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Title: Concise synthesis of the cell cycle inhibitor demothoxyfumitremorgin C
Authors: Wang, H. 
Ganesan, A. 
Issue Date: 16-Jun-1997
Citation: Wang, H., Ganesan, A. (1997-06-16). Concise synthesis of the cell cycle inhibitor demothoxyfumitremorgin C. Tetrahedron Letters 38 (24) : 4327-4328. ScholarBank@NUS Repository.
Abstract: Reaction of the imine derived from L-tryptophan methyl ester and senecialdehyde with Fmoc-L-Pro-Cl induces an acyliminium Pictet-Spengler condensation, yielding a mixture of cis and trans tetrahydro-β-carbolines. Deprotection of the cis product with concomitant diketopiperazine formation afforded the natural product in 20% overall yield.
Source Title: Tetrahedron Letters
ISSN: 00404039
DOI: 10.1016/S0040-4039(97)00892-7
Appears in Collections:Staff Publications

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