Concise synthesis of the cell cycle inhibitor demothoxyfumitremorgin C

Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0040-4039(97)00892-7

Title:	Concise synthesis of the cell cycle inhibitor demothoxyfumitremorgin C
Authors:	Wang, H. Ganesan, A.
Issue Date:	16-Jun-1997
Citation:	Wang, H., Ganesan, A. (1997-06-16). Concise synthesis of the cell cycle inhibitor demothoxyfumitremorgin C. Tetrahedron Letters 38 (24) : 4327-4328. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(97)00892-7
Abstract:	Reaction of the imine derived from L-tryptophan methyl ester and senecialdehyde with Fmoc-L-Pro-Cl induces an acyliminium Pictet-Spengler condensation, yielding a mixture of cis and trans tetrahydro-β-carbolines. Deprotection of the cis product with concomitant diketopiperazine formation afforded the natural product in 20% overall yield.
Source Title:	Tetrahedron Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/111834
ISSN:	00404039
DOI:	10.1016/S0040-4039(97)00892-7
Appears in Collections:	Staff Publications

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