Please use this identifier to cite or link to this item: https://doi.org/10.1002/1522-7189(199911/12)7:6<361::AID-NT79>3.0.CO;2-1
Title: Detection of diarrhetic shellfish poisoning toxins from tropical shellfish using liquid chromatography-selected reaction monitoring mass spectrometry
Authors: Holmes, M.J. 
Teo, S.L.M. 
Khoo, H.W. 
Keywords: Diarrhetic shellfish poisoning
Mass spectrometry
Mussels
Okadaic acid
Singapore
Issue Date: 1999
Citation: Holmes, M.J., Teo, S.L.M., Khoo, H.W. (1999). Detection of diarrhetic shellfish poisoning toxins from tropical shellfish using liquid chromatography-selected reaction monitoring mass spectrometry. Natural Toxins 7 (6) : 361-364. ScholarBank@NUS Repository. https://doi.org/10.1002/1522-7189(199911/12)7:6<361::AID-NT79>3.0.CO;2-1
Abstract: A negative mode liquid chromatography-selected reaction monitoring mass spectrometry (LC-SRM MS) method was developed to detect low concentrations of the diarrhetic shellfish poisoning (DSP) toxins okadaic acid and dinophysistoxin-1 (DTX-1). Detection relies upon monitoring the transition of negative precursor ions [M - H]- to a common fragment ion of m/z 255. Our limit of detection for okadaic acid with this method is 0.5 pg on column. LC-SRM MS has allowed us to detect persistent low concentrations of DSP toxins from Singapore shellfish. Copyright © 1999 John Wiley & Sons, Ltd.
Source Title: Natural Toxins
URI: http://scholarbank.nus.edu.sg/handle/10635/111722
ISSN: 10569014
DOI: 10.1002/1522-7189(199911/12)7:6<361::AID-NT79>3.0.CO;2-1
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