Please use this identifier to cite or link to this item: https://doi.org/10.1117/1.3497565
Title: Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy
Authors: Raja, A.M.
Xu, S.
Sun, W.
Zhou, J. 
Tai, D.C.S.
Chen, C.-S.
Rajapakse, J.C.
So, P.T.C.
Yu, H. 
Keywords: collagen modulation postchemotherapy
drug resistance
pulse modulation
second harmonic generation imaging
Issue Date: Sep-2010
Citation: Raja, A.M., Xu, S., Sun, W., Zhou, J., Tai, D.C.S., Chen, C.-S., Rajapakse, J.C., So, P.T.C., Yu, H. (2010-09). Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy. Journal of Biomedical Optics 15 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1117/1.3497565
Abstract: Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid leukemia (AML) tumor specimens treated with a new drug against receptor tyrosine kinase (ABT-869), and observe a significant increase in collagen area percentage, collagen fiber length, fiber width, and fiber number after chemotherapy. This finding reveals new insights into tumor responses to chemotherapy and suggests caution in developing new drugs and therapeutic regimens against cancers. © 2010 Society of Photo-Optical Instrumentation Engineers.
Source Title: Journal of Biomedical Optics
URI: http://scholarbank.nus.edu.sg/handle/10635/110773
ISSN: 10833668
DOI: 10.1117/1.3497565
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