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https://doi.org/10.1117/1.3497565
| Title: | Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy | Authors: | Raja, A.M. Xu, S. Sun, W. Zhou, J. Tai, D.C.S. Chen, C.-S. Rajapakse, J.C. So, P.T.C. Yu, H. |
Keywords: | collagen modulation postchemotherapy drug resistance pulse modulation second harmonic generation imaging |
Issue Date: | Sep-2010 | Citation: | Raja, A.M., Xu, S., Sun, W., Zhou, J., Tai, D.C.S., Chen, C.-S., Rajapakse, J.C., So, P.T.C., Yu, H. (2010-09). Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy. Journal of Biomedical Optics 15 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1117/1.3497565 | Abstract: | Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid leukemia (AML) tumor specimens treated with a new drug against receptor tyrosine kinase (ABT-869), and observe a significant increase in collagen area percentage, collagen fiber length, fiber width, and fiber number after chemotherapy. This finding reveals new insights into tumor responses to chemotherapy and suggests caution in developing new drugs and therapeutic regimens against cancers. © 2010 Society of Photo-Optical Instrumentation Engineers. | Source Title: | Journal of Biomedical Optics | URI: | http://scholarbank.nus.edu.sg/handle/10635/110773 | ISSN: | 10833668 | DOI: | 10.1117/1.3497565 |
| Appears in Collections: | Staff Publications |
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