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Please use this identifier to cite or link to this item: https://doi.org/10.1117/1.3497565
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dc.titlePulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy
dc.contributor.authorRaja, A.M.
dc.contributor.authorXu, S.
dc.contributor.authorSun, W.
dc.contributor.authorZhou, J.
dc.contributor.authorTai, D.C.S.
dc.contributor.authorChen, C.-S.
dc.contributor.authorRajapakse, J.C.
dc.contributor.authorSo, P.T.C.
dc.contributor.authorYu, H.
dc.date.accessioned2014-11-26T10:00:06Z
dc.date.available2014-11-26T10:00:06Z
dc.date.issued2010-09
dc.identifier.citationRaja, A.M., Xu, S., Sun, W., Zhou, J., Tai, D.C.S., Chen, C.-S., Rajapakse, J.C., So, P.T.C., Yu, H. (2010-09). Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy. Journal of Biomedical Optics 15 (5) : -. ScholarBank@NUS Repository. https://doi.org/10.1117/1.3497565
dc.identifier.issn10833668
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110773
dc.description.abstractPulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of human acute myeloid leukemia (AML) tumor specimens treated with a new drug against receptor tyrosine kinase (ABT-869), and observe a significant increase in collagen area percentage, collagen fiber length, fiber width, and fiber number after chemotherapy. This finding reveals new insights into tumor responses to chemotherapy and suggests caution in developing new drugs and therapeutic regimens against cancers. © 2010 Society of Photo-Optical Instrumentation Engineers.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1117/1.3497565
dc.sourceScopus
dc.subjectcollagen modulation postchemotherapy
dc.subjectdrug resistance
dc.subjectpulse modulation
dc.subjectsecond harmonic generation imaging
dc.typeArticle
dc.contributor.departmentNATIONAL UNIVERSITY MEDICAL INSTITUTES
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1117/1.3497565
dc.description.sourcetitleJournal of Biomedical Optics
dc.description.volume15
dc.description.issue5
dc.description.page-
dc.description.codenJBOPF
dc.identifier.isiut000284837400038
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