Please use this identifier to cite or link to this item: https://doi.org/10.7314/APJCP.2012.13.5.2139
Title: ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China
Authors: Wen, Y.-Y.
Pan, X.-F.
Loh, M.
Tian, Z.
Yang, S.-J.
Lv, S.-H.
Huang, W.-Z.
Huang, H.
Xie, Y.
Soong, R. 
Yang, C.-X.
Keywords: ADPRT
China
Gastric cancer
Polymorphisms
Risk
XRCC1
Issue Date: 2012
Citation: Wen, Y.-Y., Pan, X.-F., Loh, M., Tian, Z., Yang, S.-J., Lv, S.-H., Huang, W.-Z., Huang, H., Xie, Y., Soong, R., Yang, C.-X. (2012). ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China. Asian Pacific Journal of Cancer Prevention 13 (5) : 2139-2144. ScholarBank@NUS Repository. https://doi.org/10.7314/APJCP.2012.13.5.2139
Abstract: Objective: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trp and ADPRT Val762Ala may be associated with risk. Methods: We designed a multicenter 1:1 matched case-control study of 307 pairs of gastric cancers and controls between October 2010 and August 2011. XRCC1 Arg194Trp and ADPRT Val762Ala were sequenced, and demographic data as well as lifestyle factors were collected using a self-designed questionnaire. Results: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variant genotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the OR for ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737). No gene-gene or gene-environment interactions were found. In addition, family history of cancer and drinkers proportion were higher among cases than among controls (P
Source Title: Asian Pacific Journal of Cancer Prevention
URI: http://scholarbank.nus.edu.sg/handle/10635/110720
ISSN: 15137368
DOI: 10.7314/APJCP.2012.13.5.2139
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