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https://doi.org/10.1017/S0033291711001280
| Title: | A practical approach to the early identification of antidepressant medication non-responders | Authors: | Li, J. Kuk, A.Y.C. Rush, A.J. |
Keywords: | Antidepressant medication cross-validation diagnostic medicine negative predictive value recursive subsetting |
Issue Date: | Feb-2012 | Citation: | Li, J., Kuk, A.Y.C., Rush, A.J. (2012-02). A practical approach to the early identification of antidepressant medication non-responders. Psychological Medicine 42 (2) : 309-316. ScholarBank@NUS Repository. https://doi.org/10.1017/S0033291711001280 | Abstract: | Background The aim of the present study was to determine whether a combination of baseline features and early post-baseline depressive symptom changes have clinical value in predicting out-patient non-response in depressed out-patients after 8 weeks of medication treatment.Method We analysed data from the Combining Medications to Enhance Depression Outcomes study for 447 participants with complete 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR 16) ratings at baseline and at treatment weeks 2, 4 and 8. We used a multi-time point, recursive subsetting approach that included baseline features and changes in QIDS-SR 16 scores from baseline to weeks 2 and 4, to identify non-responders ( | Source Title: | Psychological Medicine | URI: | http://scholarbank.nus.edu.sg/handle/10635/110475 | ISSN: | 00332917 | DOI: | 10.1017/S0033291711001280 |
| Appears in Collections: | Staff Publications |
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