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Title: A practical approach to the early identification of antidepressant medication non-responders
Authors: Li, J. 
Kuk, A.Y.C. 
Rush, A.J. 
Keywords: Antidepressant medication
diagnostic medicine
negative predictive value
recursive subsetting
Issue Date: Feb-2012
Citation: Li, J., Kuk, A.Y.C., Rush, A.J. (2012-02). A practical approach to the early identification of antidepressant medication non-responders. Psychological Medicine 42 (2) : 309-316. ScholarBank@NUS Repository.
Abstract: Background The aim of the present study was to determine whether a combination of baseline features and early post-baseline depressive symptom changes have clinical value in predicting out-patient non-response in depressed out-patients after 8 weeks of medication treatment.Method We analysed data from the Combining Medications to Enhance Depression Outcomes study for 447 participants with complete 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR 16) ratings at baseline and at treatment weeks 2, 4 and 8. We used a multi-time point, recursive subsetting approach that included baseline features and changes in QIDS-SR 16 scores from baseline to weeks 2 and 4, to identify non-responders (
Source Title: Psychological Medicine
ISSN: 00332917
DOI: 10.1017/S0033291711001280
Appears in Collections:Staff Publications

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