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Title: The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency
Authors: Cao, H.
Marcy, G. 
Goh, E.L.K. 
Wang, F.
Wang, J.
Chew, S.Y.
Keywords: Electrospinning
Neural tissue engineering
Issue Date: May-2012
Citation: Cao, H., Marcy, G., Goh, E.L.K., Wang, F., Wang, J., Chew, S.Y. (2012-05). The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency. Macromolecular Bioscience 12 (5) : 666-674. ScholarBank@NUS Repository.
Abstract: Astrocyte-nanofiber interactions are studied by culturing primary rat cortical astrocytes on poly[caprolactone-co-(ethyl ethylene phosphate)] electrospun nanofibers and solvent-cast films (two-dimensional control). The results indicate that nanofiber topography significantly suppresses astrocyte proliferation and enhances apoptosis, without altering cellular activation as compared to films. Moreover, nanofiber topography enhances gene-silencing efficiency in astrocytes. The results suggest that nanofibers may serve as potential substrates for nerve regeneration by suppressing astrocyte growth and may further facilitate the use of gene-silencing to enhance CNS regeneration. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Macromolecular Bioscience
ISSN: 16165187
DOI: 10.1002/mabi.201100436
Appears in Collections:Staff Publications

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