The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency

Please use this identifier to cite or link to this item: https://doi.org/10.1002/mabi.201100436

Title:	The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency
Authors:	Cao, H. Marcy, G. Goh, E.L.K. Wang, F. Wang, J. Chew, S.Y.
Keywords:	Electrospinning Fibers Films Neural tissue engineering SiRNA
Issue Date:	May-2012
Citation:	Cao, H., Marcy, G., Goh, E.L.K., Wang, F., Wang, J., Chew, S.Y. (2012-05). The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency. Macromolecular Bioscience 12 (5) : 666-674. ScholarBank@NUS Repository. https://doi.org/10.1002/mabi.201100436
Abstract:	Astrocyte-nanofiber interactions are studied by culturing primary rat cortical astrocytes on poly[caprolactone-co-(ethyl ethylene phosphate)] electrospun nanofibers and solvent-cast films (two-dimensional control). The results indicate that nanofiber topography significantly suppresses astrocyte proliferation and enhances apoptosis, without altering cellular activation as compared to films. Moreover, nanofiber topography enhances gene-silencing efficiency in astrocytes. The results suggest that nanofibers may serve as potential substrates for nerve regeneration by suppressing astrocyte growth and may further facilitate the use of gene-silencing to enhance CNS regeneration. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title:	Macromolecular Bioscience
URI:	http://scholarbank.nus.edu.sg/handle/10635/110310
ISSN:	16165187
DOI:	10.1002/mabi.201100436
Appears in Collections:	Staff Publications

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