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|Title:||The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency||Authors:||Cao, H.
Neural tissue engineering
|Issue Date:||May-2012||Citation:||Cao, H., Marcy, G., Goh, E.L.K., Wang, F., Wang, J., Chew, S.Y. (2012-05). The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency. Macromolecular Bioscience 12 (5) : 666-674. ScholarBank@NUS Repository. https://doi.org/10.1002/mabi.201100436||Abstract:||Astrocyte-nanofiber interactions are studied by culturing primary rat cortical astrocytes on poly[caprolactone-co-(ethyl ethylene phosphate)] electrospun nanofibers and solvent-cast films (two-dimensional control). The results indicate that nanofiber topography significantly suppresses astrocyte proliferation and enhances apoptosis, without altering cellular activation as compared to films. Moreover, nanofiber topography enhances gene-silencing efficiency in astrocytes. The results suggest that nanofibers may serve as potential substrates for nerve regeneration by suppressing astrocyte growth and may further facilitate the use of gene-silencing to enhance CNS regeneration. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.||Source Title:||Macromolecular Bioscience||URI:||http://scholarbank.nus.edu.sg/handle/10635/110310||ISSN:||16165187||DOI:||10.1002/mabi.201100436|
|Appears in Collections:||Staff Publications|
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