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Please use this identifier to cite or link to this item: https://doi.org/10.1002/mabi.201100436
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dc.titleThe Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency
dc.contributor.authorCao, H.
dc.contributor.authorMarcy, G.
dc.contributor.authorGoh, E.L.K.
dc.contributor.authorWang, F.
dc.contributor.authorWang, J.
dc.contributor.authorChew, S.Y.
dc.date.accessioned2014-11-26T08:30:56Z
dc.date.available2014-11-26T08:30:56Z
dc.date.issued2012-05
dc.identifier.citationCao, H., Marcy, G., Goh, E.L.K., Wang, F., Wang, J., Chew, S.Y. (2012-05). The Effects of Nanofiber Topography on Astrocyte Behavior and Gene Silencing Efficiency. Macromolecular Bioscience 12 (5) : 666-674. ScholarBank@NUS Repository. https://doi.org/10.1002/mabi.201100436
dc.identifier.issn16165187
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/110310
dc.description.abstractAstrocyte-nanofiber interactions are studied by culturing primary rat cortical astrocytes on poly[caprolactone-co-(ethyl ethylene phosphate)] electrospun nanofibers and solvent-cast films (two-dimensional control). The results indicate that nanofiber topography significantly suppresses astrocyte proliferation and enhances apoptosis, without altering cellular activation as compared to films. Moreover, nanofiber topography enhances gene-silencing efficiency in astrocytes. The results suggest that nanofibers may serve as potential substrates for nerve regeneration by suppressing astrocyte growth and may further facilitate the use of gene-silencing to enhance CNS regeneration. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/mabi.201100436
dc.sourceScopus
dc.subjectElectrospinning
dc.subjectFibers
dc.subjectFilms
dc.subjectNeural tissue engineering
dc.subjectSiRNA
dc.typeArticle
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1002/mabi.201100436
dc.description.sourcetitleMacromolecular Bioscience
dc.description.volume12
dc.description.issue5
dc.description.page666-674
dc.description.codenMBAIB
dc.identifier.isiut000303661300012
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