Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ajo.2006.07.040
Title: Is Early Age-related Macular Degeneration Associated With Cerebral MRI Changes? The Atherosclerosis Risk in Communities Study
Authors: Grosso, A.
Mosley, T.H.
Klein, R.
Couper, D.J.
Tikellis, G.
Wong, T.Y. 
Issue Date: Jan-2007
Citation: Grosso, A., Mosley, T.H., Klein, R., Couper, D.J., Tikellis, G., Wong, T.Y. (2007-01). Is Early Age-related Macular Degeneration Associated With Cerebral MRI Changes? The Atherosclerosis Risk in Communities Study. American Journal of Ophthalmology 143 (1) : 157-159. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ajo.2006.07.040
Abstract: Purpose: To examine the relation of early age-related macular degeneration (AMD) with cerebral magnetic resonance imaging (MRI) changes. Design: Population-based, cross-sectional study. Methods: A sample of 1,684 persons ages 51 to 72 years with no history of stroke had cerebral MRI and retinal photography. MRI scans were graded for severity of white matter lesions (WML), sulcal widening (SW), and ventricular enlargement (VE). AMD was graded from retinal photographs. Results: After adjustment for age, gender, race, or center, early AMD (5.0% of participants) was not significantly associated with WML (odds ratio [OR] 1.0, 95% confidence intervals [CI], 0.6 to 1.6), SW (OR 0.6, 95% CI, 0.4 to 1.2), or VE (OR 1.0, 95% CI, 0.6 to 1.8). Conclusions: These data showed no statistically significant association of early AMD with cerebral MRI changes, but the study was limited by a small number of cases with wide CIs. Further studies may clarify these associations. © 2007 Elsevier Inc. All rights reserved.
Source Title: American Journal of Ophthalmology
URI: http://scholarbank.nus.edu.sg/handle/10635/109425
ISSN: 00029394
DOI: 10.1016/j.ajo.2006.07.040
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

5
checked on Sep 12, 2019

WEB OF SCIENCETM
Citations

6
checked on Sep 12, 2019

Page view(s)

34
checked on Sep 7, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.