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Title: Validity of EuroQOL-5D, time trade-off, and standard gamble for age-related macular degeneration in the Singapore population
Authors: Au Eong, K.G.
Chan, E.W.
Luo, N. 
Wong, S.H.
Tan, N.W.H.
Lim, T.H.
Wagle, A.M.
Keywords: age-related macular degeneration
quality of life
utility values
Issue Date: Mar-2012
Citation: Au Eong, K.G., Chan, E.W., Luo, N., Wong, S.H., Tan, N.W.H., Lim, T.H., Wagle, A.M. (2012-03). Validity of EuroQOL-5D, time trade-off, and standard gamble for age-related macular degeneration in the Singapore population. Eye 26 (3) : 379-388. ScholarBank@NUS Repository.
Abstract: Background/aims: Utility values of age-related macular degeneration (AMD) in Asian patients are unknown. This study aims to assess utility values and construct validity of the EuroQOL-5D (EQ-5D), time trade-off (TTO), and standard gamble (SG) instruments in the Singapore multi-ethnic AMD population. Methods: Cross-sectional, two-centre, institution-based study. Visual acuity (VA), clinical AMD severity, and utility scores on the EQ-5D, TTO, and SG were obtained from 338 AMD patients. VA was analysed in terms of the better-seeing eye (BEVA), worse-seeing eye (WEVA), and weighted average of both eyes (WVA). We evaluated SG on the perfect health-death (SG(death)) and binocular perfect vision-binocular blindness (SG(blindness)) scales. Construct validity was determined by testing a priorihypotheses relating the EQ-5D, TTO, and SG utility scores to VA and clinical AMD severity. Results: The mean utilities on the EQ-5D, TTO, SG(death), and SG(blindness) were 0.89, 0.81, 0.86, and 0.90, respectively. EQ-5D scores correlated weakly with BEVA, WEVA, and WVA (Pearson's correlation coefficients -0.291, -0.247, and -0.305 respectively, P
Source Title: Eye
ISSN: 0950222X
DOI: 10.1038/eye.2011.218
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