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https://doi.org/10.1038/eye.2011.218
Title: | Validity of EuroQOL-5D, time trade-off, and standard gamble for age-related macular degeneration in the Singapore population | Authors: | Au Eong, K.G. Chan, E.W. Luo, N. Wong, S.H. Tan, N.W.H. Lim, T.H. Wagle, A.M. |
Keywords: | age-related macular degeneration quality of life utility values |
Issue Date: | Mar-2012 | Citation: | Au Eong, K.G., Chan, E.W., Luo, N., Wong, S.H., Tan, N.W.H., Lim, T.H., Wagle, A.M. (2012-03). Validity of EuroQOL-5D, time trade-off, and standard gamble for age-related macular degeneration in the Singapore population. Eye 26 (3) : 379-388. ScholarBank@NUS Repository. https://doi.org/10.1038/eye.2011.218 | Abstract: | Background/aims: Utility values of age-related macular degeneration (AMD) in Asian patients are unknown. This study aims to assess utility values and construct validity of the EuroQOL-5D (EQ-5D), time trade-off (TTO), and standard gamble (SG) instruments in the Singapore multi-ethnic AMD population. Methods: Cross-sectional, two-centre, institution-based study. Visual acuity (VA), clinical AMD severity, and utility scores on the EQ-5D, TTO, and SG were obtained from 338 AMD patients. VA was analysed in terms of the better-seeing eye (BEVA), worse-seeing eye (WEVA), and weighted average of both eyes (WVA). We evaluated SG on the perfect health-death (SG(death)) and binocular perfect vision-binocular blindness (SG(blindness)) scales. Construct validity was determined by testing a priorihypotheses relating the EQ-5D, TTO, and SG utility scores to VA and clinical AMD severity. Results: The mean utilities on the EQ-5D, TTO, SG(death), and SG(blindness) were 0.89, 0.81, 0.86, and 0.90, respectively. EQ-5D scores correlated weakly with BEVA, WEVA, and WVA (Pearson's correlation coefficients -0.291, -0.247, and -0.305 respectively, P | Source Title: | Eye | URI: | http://scholarbank.nus.edu.sg/handle/10635/108827 | ISSN: | 0950222X | DOI: | 10.1038/eye.2011.218 |
Appears in Collections: | Staff Publications |
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