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Title: Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population
Authors: Tan, D.E.K.
Foo, J.N.
Bei, J.-X.
Chang, J.
Peng, R.
Zheng, X.
Wei, L.
Huang, Y.
Lim, W.Y. 
Li, J.
Cui, Q.
Chew, S.H. 
Ebstein, R.P.
Kuperan, P.
Lim, S.T.
Tao, M.
Tan, S.H.
Wong, A.
Wong, G.C.
Tan, S.Y.
Ng, S.B.
Zeng, Y.-X.
Khor, C.C. 
Lin, D.
Seow, A.L.H. 
Jia, W.-H.
Liu, J. 
Issue Date: Jul-2013
Citation: Tan, D.E.K., Foo, J.N., Bei, J.-X., Chang, J., Peng, R., Zheng, X., Wei, L., Huang, Y., Lim, W.Y., Li, J., Cui, Q., Chew, S.H., Ebstein, R.P., Kuperan, P., Lim, S.T., Tao, M., Tan, S.H., Wong, A., Wong, G.C., Tan, S.Y., Ng, S.B., Zeng, Y.-X., Khor, C.C., Lin, D., Seow, A.L.H., Jia, W.-H., Liu, J. (2013-07). Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. Nature Genetics 45 (7) : 804-807. ScholarBank@NUS Repository.
Abstract: To identify genetic risk factors underlying non-Hodgkin lymphomas (NHLs) from the B cell lineage, we conducted a genome-wide association study (GWAS) of 253 Chinese individuals with B cell NHL (cases) and 1,438 controls and further validation in 1,175 cases and 5,492 controls. We identified a new susceptibility locus, rs6773854, located between BCL6 (encoding B cell lymphoma protein 6) and LPP (encoding lipoma preferred partner) on oncogene-rich chromosome 3q27 that was significantly associated with increased risk of B cell NHL (meta-analysis P = 3.36 × 10 -13, per-allele odds ratio (OR) = 1.44) and with diffuse large B cell lymphoma (DLBCL) in particular (meta-analysis P = 1.14 × 10 -11, OR = 1.47). We found no evidence of association of rs6773854 with non-B cell NHLs (T cell and natural killer (NK) lineages) (P = 0.17, OR = 1.12) and observed significant heterogeneity between B cell and non-B cell subtypes (P het = 0.01, I 2 = 84%). Our results provide insight that germline variation in the intergenic region between BCL6 and LPP has a role in risk of B cell lymphomagenesis. © 2013 Nature America, Inc. All rights reserved.
Source Title: Nature Genetics
ISSN: 10614036
DOI: 10.1038/ng.2666
Appears in Collections:Staff Publications

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