Please use this identifier to cite or link to this item:
https://doi.org/10.1038/ng.2666
DC Field | Value | |
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dc.title | Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population | |
dc.contributor.author | Tan, D.E.K. | |
dc.contributor.author | Foo, J.N. | |
dc.contributor.author | Bei, J.-X. | |
dc.contributor.author | Chang, J. | |
dc.contributor.author | Peng, R. | |
dc.contributor.author | Zheng, X. | |
dc.contributor.author | Wei, L. | |
dc.contributor.author | Huang, Y. | |
dc.contributor.author | Lim, W.Y. | |
dc.contributor.author | Li, J. | |
dc.contributor.author | Cui, Q. | |
dc.contributor.author | Chew, S.H. | |
dc.contributor.author | Ebstein, R.P. | |
dc.contributor.author | Kuperan, P. | |
dc.contributor.author | Lim, S.T. | |
dc.contributor.author | Tao, M. | |
dc.contributor.author | Tan, S.H. | |
dc.contributor.author | Wong, A. | |
dc.contributor.author | Wong, G.C. | |
dc.contributor.author | Tan, S.Y. | |
dc.contributor.author | Ng, S.B. | |
dc.contributor.author | Zeng, Y.-X. | |
dc.contributor.author | Khor, C.C. | |
dc.contributor.author | Lin, D. | |
dc.contributor.author | Seow, A.L.H. | |
dc.contributor.author | Jia, W.-H. | |
dc.contributor.author | Liu, J. | |
dc.date.accessioned | 2014-11-26T02:12:30Z | |
dc.date.available | 2014-11-26T02:12:30Z | |
dc.date.issued | 2013-07 | |
dc.identifier.citation | Tan, D.E.K., Foo, J.N., Bei, J.-X., Chang, J., Peng, R., Zheng, X., Wei, L., Huang, Y., Lim, W.Y., Li, J., Cui, Q., Chew, S.H., Ebstein, R.P., Kuperan, P., Lim, S.T., Tao, M., Tan, S.H., Wong, A., Wong, G.C., Tan, S.Y., Ng, S.B., Zeng, Y.-X., Khor, C.C., Lin, D., Seow, A.L.H., Jia, W.-H., Liu, J. (2013-07). Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population. Nature Genetics 45 (7) : 804-807. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2666 | |
dc.identifier.issn | 10614036 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/108761 | |
dc.description.abstract | To identify genetic risk factors underlying non-Hodgkin lymphomas (NHLs) from the B cell lineage, we conducted a genome-wide association study (GWAS) of 253 Chinese individuals with B cell NHL (cases) and 1,438 controls and further validation in 1,175 cases and 5,492 controls. We identified a new susceptibility locus, rs6773854, located between BCL6 (encoding B cell lymphoma protein 6) and LPP (encoding lipoma preferred partner) on oncogene-rich chromosome 3q27 that was significantly associated with increased risk of B cell NHL (meta-analysis P = 3.36 × 10 -13, per-allele odds ratio (OR) = 1.44) and with diffuse large B cell lymphoma (DLBCL) in particular (meta-analysis P = 1.14 × 10 -11, OR = 1.47). We found no evidence of association of rs6773854 with non-B cell NHLs (T cell and natural killer (NK) lineages) (P = 0.17, OR = 1.12) and observed significant heterogeneity between B cell and non-B cell subtypes (P het = 0.01, I 2 = 84%). Our results provide insight that germline variation in the intergenic region between BCL6 and LPP has a role in risk of B cell lymphomagenesis. © 2013 Nature America, Inc. All rights reserved. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/ng.2666 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.contributor.department | ECONOMICS | |
dc.description.doi | 10.1038/ng.2666 | |
dc.description.sourcetitle | Nature Genetics | |
dc.description.volume | 45 | |
dc.description.issue | 7 | |
dc.description.page | 804-807 | |
dc.description.coden | NGENE | |
dc.identifier.isiut | 000321005200016 | |
Appears in Collections: | Staff Publications |
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