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Title: Mammographic density and its interaction with other breast cancer risk factors in an Asian population
Authors: Wong, C.S. 
Lim, G.H.
Gao, F. 
Jakes, R.W.
Offman, J.
Chia, K.S. 
Duffy, S.W.
Keywords: Asian population
body mass index
breast cancer
breast density
Issue Date: 1-Mar-2011
Citation: Wong, C.S., Lim, G.H., Gao, F., Jakes, R.W., Offman, J., Chia, K.S., Duffy, S.W. (2011-03-01). Mammographic density and its interaction with other breast cancer risk factors in an Asian population. British Journal of Cancer 104 (5) : 871-874. ScholarBank@NUS Repository.
Abstract: Background: Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear. Methods: From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression. Results: Density was a significant risk factor, adjusting for other factors. Density of 76-100% had an odds ratio of 5.54 (95% CI 2.38-12.90) compared with 0-10%. Density had significant interactions with body mass index and oral contraceptive use (P=0.02).Conclusions:Percent density increases breast cancer risk in addition to effects of other risk factors, and modifies the effects of BMI and OCs. © 2011 Cancer Research UK All rights reserved.
Source Title: British Journal of Cancer
ISSN: 00070920
DOI: 10.1038/sj.bjc.6606085
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