Please use this identifier to cite or link to this item:
|Title:||AMIGO is expressed in multiple brain cell types and may regulate dendritic growth and neuronal survival||Authors:||Chen, Y.
|Issue Date:||May-2012||Citation:||Chen, Y., Hor, H.H., Tang, B.L. (2012-05). AMIGO is expressed in multiple brain cell types and may regulate dendritic growth and neuronal survival. Journal of Cellular Physiology 227 (5) : 2217-2229. ScholarBank@NUS Repository. https://doi.org/10.1002/jcp.22958||Abstract:||Amphoterin-induced gene and ORF (AMIGO) is a brain-enriched transmembrane immunoglobulin (Ig) superfamily protein with six extracellular leucine-rich repeats (LRR) and a single immunoglobulin-like (Ig) domain. We report here that AMIGO is a glycosylated protein widely expressed in the central nervous system (CNS), and can be found in neurons, astrocytes as well as oligodendrocytes. In morphologically mature primary neurons, endogenous AMIGO, and transfected full length AMIGO (AMIGO-FL) are largely dendritic, while AMIGO with its LRR domain deleted (AMIGO-Ig) is predominantly axonal. In line with AMIGO's dendritic localization, siRNA-mediated silencing of AMIGO resulted in reduced dendritic growth of cortical neurons in culture. SH-SY5Y cells stably over-expressing AMIGO are more resistant to apoptosis induced by staurosporine and H 2O 2 compared to vector controls. AMIGO therefore likely plays important roles in dendritic outgrowth during development, and could modulate the survival of developing and adult neurons. © 2011 Wiley Periodicals, Inc.||Source Title:||Journal of Cellular Physiology||URI:||http://scholarbank.nus.edu.sg/handle/10635/108254||ISSN:||00219541||DOI:||10.1002/jcp.22958|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Apr 4, 2020
WEB OF SCIENCETM
checked on Mar 19, 2020
checked on Mar 28, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.