Please use this identifier to cite or link to this item: https://doi.org/10.1002/jcp.22958
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dc.titleAMIGO is expressed in multiple brain cell types and may regulate dendritic growth and neuronal survival
dc.contributor.authorChen, Y.
dc.contributor.authorHor, H.H.
dc.contributor.authorTang, B.L.
dc.date.accessioned2014-11-25T09:43:48Z
dc.date.available2014-11-25T09:43:48Z
dc.date.issued2012-05
dc.identifier.citationChen, Y., Hor, H.H., Tang, B.L. (2012-05). AMIGO is expressed in multiple brain cell types and may regulate dendritic growth and neuronal survival. Journal of Cellular Physiology 227 (5) : 2217-2229. ScholarBank@NUS Repository. https://doi.org/10.1002/jcp.22958
dc.identifier.issn00219541
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/108254
dc.description.abstractAmphoterin-induced gene and ORF (AMIGO) is a brain-enriched transmembrane immunoglobulin (Ig) superfamily protein with six extracellular leucine-rich repeats (LRR) and a single immunoglobulin-like (Ig) domain. We report here that AMIGO is a glycosylated protein widely expressed in the central nervous system (CNS), and can be found in neurons, astrocytes as well as oligodendrocytes. In morphologically mature primary neurons, endogenous AMIGO, and transfected full length AMIGO (AMIGO-FL) are largely dendritic, while AMIGO with its LRR domain deleted (AMIGO-Ig) is predominantly axonal. In line with AMIGO's dendritic localization, siRNA-mediated silencing of AMIGO resulted in reduced dendritic growth of cortical neurons in culture. SH-SY5Y cells stably over-expressing AMIGO are more resistant to apoptosis induced by staurosporine and H 2O 2 compared to vector controls. AMIGO therefore likely plays important roles in dendritic outgrowth during development, and could modulate the survival of developing and adult neurons. © 2011 Wiley Periodicals, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jcp.22958
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1002/jcp.22958
dc.description.sourcetitleJournal of Cellular Physiology
dc.description.volume227
dc.description.issue5
dc.description.page2217-2229
dc.description.codenJCLLA
dc.identifier.isiut000299373900048
Appears in Collections:Staff Publications

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