Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity

Please use this identifier to cite or link to this item: https://doi.org/10.1002/cmdc.200900379

Title:	Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity
Authors:	Knijnenburg, A.D. Spalburg, E. De Neeling, A.J. Mars-Groenendijk, R.H. Noort, D. Grotenbreg, G.M. Van Der Marel, G.A. Overkleeft, H.S. Overhand, M.
Keywords:	β turns Antibiotics Cyclic peptides Gramicidin S Sugar amino acids
Issue Date:	7-Dec-2009
Citation:	Knijnenburg, A.D., Spalburg, E., De Neeling, A.J., Mars-Groenendijk, R.H., Noort, D., Grotenbreg, G.M., Van Der Marel, G.A., Overkleeft, H.S., Overhand, M. (2009-12-07). Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity. ChemMedChem 4 (12) : 1976-1979. ScholarBank@NUS Repository. https://doi.org/10.1002/cmdc.200900379
Abstract:	(Chemical Equation Presented) A series of ring-extended gramicidin S (GS) derivatives containing furanoid sugar amino acids were evaluated. Although the extended GS derivatives have a less well-defined secondary structure as determined by NMR and CD, some derivatives show an improved biological profile, namely, an increased antibacterial activity and decreased hemolytic activity. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Source Title:	ChemMedChem
URI:	http://scholarbank.nus.edu.sg/handle/10635/107632
ISSN:	18607179
DOI:	10.1002/cmdc.200900379
Appears in Collections:	Staff Publications

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