Please use this identifier to cite or link to this item: https://doi.org/10.1002/cmdc.200900379
Title: Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity
Authors: Knijnenburg, A.D.
Spalburg, E.
De Neeling, A.J.
Mars-Groenendijk, R.H.
Noort, D.
Grotenbreg, G.M. 
Van Der Marel, G.A.
Overkleeft, H.S.
Overhand, M.
Keywords: β turns
Antibiotics
Cyclic peptides
Gramicidin S
Sugar amino acids
Issue Date: 7-Dec-2009
Citation: Knijnenburg, A.D., Spalburg, E., De Neeling, A.J., Mars-Groenendijk, R.H., Noort, D., Grotenbreg, G.M., Van Der Marel, G.A., Overkleeft, H.S., Overhand, M. (2009-12-07). Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity. ChemMedChem 4 (12) : 1976-1979. ScholarBank@NUS Repository. https://doi.org/10.1002/cmdc.200900379
Abstract: (Chemical Equation Presented) A series of ring-extended gramicidin S (GS) derivatives containing furanoid sugar amino acids were evaluated. Although the extended GS derivatives have a less well-defined secondary structure as determined by NMR and CD, some derivatives show an improved biological profile, namely, an increased antibacterial activity and decreased hemolytic activity. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Source Title: ChemMedChem
URI: http://scholarbank.nus.edu.sg/handle/10635/107632
ISSN: 18607179
DOI: 10.1002/cmdc.200900379
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