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|Title:||The structure of the acetylcholinesterase active center and the mode of acetylcholine/acetylcholinesterase interaction. A theoretical study||Authors:||Ngiam, T.L.
|Issue Date:||1987||Citation:||Ngiam, T.L.,Go, M.L. (1987). The structure of the acetylcholinesterase active center and the mode of acetylcholine/acetylcholinesterase interaction. A theoretical study. Asia Pacific Journal of Pharmacology 2 (1) : 33-41. ScholarBank@NUS Repository.||Abstract:||Based on a theoretical consideration of the enzyme kinetic data of a selected group of compounds, a revised model of the acetylcholinesterase (AChE) active center and the mode of interaction between acetylcholine (ACh) and AChE are presented. It is proposed that interaction with the anionic sub-sites of the active center involves only two of the three N-methyl functions of ACh, and possibly the N-methylene group as well. The acid group of the receptor is located 3-4 Å away from the center of the anionic site in a three dimensional structure upon which the ACh molecule, with τ-N-C-C-O = +60° to +137°, can be attached.||Source Title:||Asia Pacific Journal of Pharmacology||URI:||http://scholarbank.nus.edu.sg/handle/10635/106597||ISSN:||02179687|
|Appears in Collections:||Staff Publications|
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