Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/106597
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dc.titleThe structure of the acetylcholinesterase active center and the mode of acetylcholine/acetylcholinesterase interaction. A theoretical study
dc.contributor.authorNgiam, T.L.
dc.contributor.authorGo, M.L.
dc.date.accessioned2014-10-29T02:02:19Z
dc.date.available2014-10-29T02:02:19Z
dc.date.issued1987
dc.identifier.citationNgiam, T.L.,Go, M.L. (1987). The structure of the acetylcholinesterase active center and the mode of acetylcholine/acetylcholinesterase interaction. A theoretical study. Asia Pacific Journal of Pharmacology 2 (1) : 33-41. ScholarBank@NUS Repository.
dc.identifier.issn02179687
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106597
dc.description.abstractBased on a theoretical consideration of the enzyme kinetic data of a selected group of compounds, a revised model of the acetylcholinesterase (AChE) active center and the mode of interaction between acetylcholine (ACh) and AChE are presented. It is proposed that interaction with the anionic sub-sites of the active center involves only two of the three N-methyl functions of ACh, and possibly the N-methylene group as well. The acid group of the receptor is located 3-4 Å away from the center of the anionic site in a three dimensional structure upon which the ACh molecule, with τ-N-C-C-O = +60° to +137°, can be attached.
dc.sourceScopus
dc.typeOthers
dc.contributor.departmentPHARMACY
dc.description.sourcetitleAsia Pacific Journal of Pharmacology
dc.description.volume2
dc.description.issue1
dc.description.page33-41
dc.description.codenAPJPE
dc.identifier.isiutNOT_IN_WOS
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