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|Title:||Gene mutation of thiopurine S-methyltransferase in Uygur Chinese||Authors:||Zhang, J.-P.
|Issue Date:||Mar-2004||Citation:||Zhang, J.-P., Guan, Y.-Y., Xu, A.-L., Zhou, S.-F., Wu, J.-H., Wei, H., Huang, M. (2004-03). Gene mutation of thiopurine S-methyltransferase in Uygur Chinese. European Journal of Clinical Pharmacology 60 (1) : 1-3. ScholarBank@NUS Repository. https://doi.org/10.1007/s00228-004-0730-7||Abstract:||Objective: This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese. Methods: Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations - G238C, G460A and A719G. Results: One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively. Conclusion: TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese. © Springer-Verlag 2004.||Source Title:||European Journal of Clinical Pharmacology||URI:||http://scholarbank.nus.edu.sg/handle/10635/105979||ISSN:||00316970||DOI:||10.1007/s00228-004-0730-7|
|Appears in Collections:||Staff Publications|
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