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https://doi.org/10.1007/s00228-004-0730-7
| Title: | Gene mutation of thiopurine S-methyltransferase in Uygur Chinese | Authors: | Zhang, J.-P. Guan, Y.-Y. Xu, A.-L. Zhou, S.-F. Wu, J.-H. Wei, H. Huang, M. |
Keywords: | Gene mutation S-methyltransferase Thiopurine |
Issue Date: | Mar-2004 | Citation: | Zhang, J.-P., Guan, Y.-Y., Xu, A.-L., Zhou, S.-F., Wu, J.-H., Wei, H., Huang, M. (2004-03). Gene mutation of thiopurine S-methyltransferase in Uygur Chinese. European Journal of Clinical Pharmacology 60 (1) : 1-3. ScholarBank@NUS Repository. https://doi.org/10.1007/s00228-004-0730-7 | Abstract: | Objective: This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese. Methods: Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations - G238C, G460A and A719G. Results: One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively. Conclusion: TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese. © Springer-Verlag 2004. | Source Title: | European Journal of Clinical Pharmacology | URI: | http://scholarbank.nus.edu.sg/handle/10635/105979 | ISSN: | 00316970 | DOI: | 10.1007/s00228-004-0730-7 |
| Appears in Collections: | Staff Publications |
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