Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00228-004-0730-7
Title: Gene mutation of thiopurine S-methyltransferase in Uygur Chinese
Authors: Zhang, J.-P.
Guan, Y.-Y.
Xu, A.-L.
Zhou, S.-F. 
Wu, J.-H.
Wei, H.
Huang, M.
Keywords: Gene mutation
S-methyltransferase
Thiopurine
Issue Date: Mar-2004
Citation: Zhang, J.-P., Guan, Y.-Y., Xu, A.-L., Zhou, S.-F., Wu, J.-H., Wei, H., Huang, M. (2004-03). Gene mutation of thiopurine S-methyltransferase in Uygur Chinese. European Journal of Clinical Pharmacology 60 (1) : 1-3. ScholarBank@NUS Repository. https://doi.org/10.1007/s00228-004-0730-7
Abstract: Objective: This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese. Methods: Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations - G238C, G460A and A719G. Results: One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively. Conclusion: TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese. © Springer-Verlag 2004.
Source Title: European Journal of Clinical Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/105979
ISSN: 00316970
DOI: 10.1007/s00228-004-0730-7
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Oct 16, 2018

WEB OF SCIENCETM
Citations

10
checked on Oct 8, 2018

Page view(s)

43
checked on Oct 19, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.