Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00228-004-0730-7
Title: Gene mutation of thiopurine S-methyltransferase in Uygur Chinese
Authors: Zhang, J.-P.
Guan, Y.-Y.
Xu, A.-L.
Zhou, S.-F. 
Wu, J.-H.
Wei, H.
Huang, M.
Keywords: Gene mutation
S-methyltransferase
Thiopurine
Issue Date: Mar-2004
Source: Zhang, J.-P., Guan, Y.-Y., Xu, A.-L., Zhou, S.-F., Wu, J.-H., Wei, H., Huang, M. (2004-03). Gene mutation of thiopurine S-methyltransferase in Uygur Chinese. European Journal of Clinical Pharmacology 60 (1) : 1-3. ScholarBank@NUS Repository. https://doi.org/10.1007/s00228-004-0730-7
Abstract: Objective: This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese. Methods: Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations - G238C, G460A and A719G. Results: One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively. Conclusion: TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese. © Springer-Verlag 2004.
Source Title: European Journal of Clinical Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/105979
ISSN: 00316970
DOI: 10.1007/s00228-004-0730-7
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