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Please use this identifier to cite or link to this item: https://doi.org/10.1007/s00228-004-0730-7
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dc.titleGene mutation of thiopurine S-methyltransferase in Uygur Chinese
dc.contributor.authorZhang, J.-P.
dc.contributor.authorGuan, Y.-Y.
dc.contributor.authorXu, A.-L.
dc.contributor.authorZhou, S.-F.
dc.contributor.authorWu, J.-H.
dc.contributor.authorWei, H.
dc.contributor.authorHuang, M.
dc.date.accessioned2014-10-29T01:53:21Z
dc.date.available2014-10-29T01:53:21Z
dc.date.issued2004-03
dc.identifier.citationZhang, J.-P., Guan, Y.-Y., Xu, A.-L., Zhou, S.-F., Wu, J.-H., Wei, H., Huang, M. (2004-03). Gene mutation of thiopurine S-methyltransferase in Uygur Chinese. European Journal of Clinical Pharmacology 60 (1) : 1-3. ScholarBank@NUS Repository. https://doi.org/10.1007/s00228-004-0730-7
dc.identifier.issn00316970
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105979
dc.description.abstractObjective: This study was to investigate the gene mutation of thiopurine S-methyltransferase (TPMT) in Uygur Chinese. Methods: Polymerase chain reaction-based methods were used to analyze three commonly reported inactivating mutations - G238C, G460A and A719G. Results: One TPMT*3A heterozygote and five TPMT*3C heterozygotes were found in 160 Uygur Chinese subjects, and allele frequencies of TPMT*3A and TPMT*3C were 0.3% and 1.6%, respectively. Conclusion: TPMT*3C is a common mutant allele in Uygur Chinese, while TPMT*3A is a rare mutant allele in Uygur Chinese. © Springer-Verlag 2004.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s00228-004-0730-7
dc.sourceScopus
dc.subjectGene mutation
dc.subjectS-methyltransferase
dc.subjectThiopurine
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1007/s00228-004-0730-7
dc.description.sourcetitleEuropean Journal of Clinical Pharmacology
dc.description.volume60
dc.description.issue1
dc.description.page1-3
dc.description.codenEJCPA
dc.identifier.isiut000220190300001
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