Please use this identifier to cite or link to this item:
|Title:||Chiral CE separation of warfarin in albumin containing samples||Authors:||Yau, W.-P.
|Keywords:||Capillary zone electrophoresis
Highly sulfated β-cyclodextrin
|Issue Date:||1-Apr-2002||Citation:||Yau, W.-P., Chan, E. (2002-04-01). Chiral CE separation of warfarin in albumin containing samples. Journal of Pharmaceutical and Biomedical Analysis 28 (1) : 107-123. ScholarBank@NUS Repository. https://doi.org/10.1016/S0731-7085(01)00604-5||Abstract:||A capillary zone electrophoresis method with ultraviolet (UV) absorbance detection for the chiral separation of warfarin enantiomers using highly sulfated β-cyclodextrin (β-CD) was developed and optimized. Enantiomeric separation of warfarin was characterized by high resolution and efficiency. The optimized electrophoretic conditions were subsequently applied to the analysis of warfarin extracted from spiked human serum albumin samples. This assay showed acceptable precision, with linearity in the warfarin enantiomer concentration range of 0.1-25 mg/l. The limits of detection (LOD) and quantitation (LOQ) evaluated as warfarin enantiomer concentrations in the serum samples were 0.05 and 0.15 mg/l, respectively, for each warfarin enantiomer. © 2002 Elsevier Science B.V. All rights reserved.||Source Title:||Journal of Pharmaceutical and Biomedical Analysis||URI:||http://scholarbank.nus.edu.sg/handle/10635/105725||ISSN:||07317085||DOI:||10.1016/S0731-7085(01)00604-5|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 23, 2020
WEB OF SCIENCETM
checked on Jan 15, 2020
checked on Jan 18, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.