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Title: Chiral CE separation of warfarin in albumin containing samples
Authors: Yau, W.-P. 
Chan, E. 
Keywords: Capillary zone electrophoresis
Chiral separation
Highly sulfated β-cyclodextrin
Warfarin enantiomers
Issue Date: 1-Apr-2002
Citation: Yau, W.-P., Chan, E. (2002-04-01). Chiral CE separation of warfarin in albumin containing samples. Journal of Pharmaceutical and Biomedical Analysis 28 (1) : 107-123. ScholarBank@NUS Repository.
Abstract: A capillary zone electrophoresis method with ultraviolet (UV) absorbance detection for the chiral separation of warfarin enantiomers using highly sulfated β-cyclodextrin (β-CD) was developed and optimized. Enantiomeric separation of warfarin was characterized by high resolution and efficiency. The optimized electrophoretic conditions were subsequently applied to the analysis of warfarin extracted from spiked human serum albumin samples. This assay showed acceptable precision, with linearity in the warfarin enantiomer concentration range of 0.1-25 mg/l. The limits of detection (LOD) and quantitation (LOQ) evaluated as warfarin enantiomer concentrations in the serum samples were 0.05 and 0.15 mg/l, respectively, for each warfarin enantiomer. © 2002 Elsevier Science B.V. All rights reserved.
Source Title: Journal of Pharmaceutical and Biomedical Analysis
ISSN: 07317085
DOI: 10.1016/S0731-7085(01)00604-5
Appears in Collections:Staff Publications

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