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Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0731-7085(01)00604-5
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dc.titleChiral CE separation of warfarin in albumin containing samples
dc.contributor.authorYau, W.-P.
dc.contributor.authorChan, E.
dc.date.accessioned2014-10-29T01:49:39Z
dc.date.available2014-10-29T01:49:39Z
dc.date.issued2002-04-01
dc.identifier.citationYau, W.-P., Chan, E. (2002-04-01). Chiral CE separation of warfarin in albumin containing samples. Journal of Pharmaceutical and Biomedical Analysis 28 (1) : 107-123. ScholarBank@NUS Repository. https://doi.org/10.1016/S0731-7085(01)00604-5
dc.identifier.issn07317085
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105725
dc.description.abstractA capillary zone electrophoresis method with ultraviolet (UV) absorbance detection for the chiral separation of warfarin enantiomers using highly sulfated β-cyclodextrin (β-CD) was developed and optimized. Enantiomeric separation of warfarin was characterized by high resolution and efficiency. The optimized electrophoretic conditions were subsequently applied to the analysis of warfarin extracted from spiked human serum albumin samples. This assay showed acceptable precision, with linearity in the warfarin enantiomer concentration range of 0.1-25 mg/l. The limits of detection (LOD) and quantitation (LOQ) evaluated as warfarin enantiomer concentrations in the serum samples were 0.05 and 0.15 mg/l, respectively, for each warfarin enantiomer. © 2002 Elsevier Science B.V. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0731-7085(01)00604-5
dc.sourceScopus
dc.subjectCapillary zone electrophoresis
dc.subjectChiral separation
dc.subjectHighly sulfated β-cyclodextrin
dc.subjectWarfarin enantiomers
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1016/S0731-7085(01)00604-5
dc.description.sourcetitleJournal of Pharmaceutical and Biomedical Analysis
dc.description.volume28
dc.description.issue1
dc.description.page107-123
dc.description.codenJPBAD
dc.identifier.isiut000174638200012
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