Please use this identifier to cite or link to this item:
https://doi.org/10.1351/PAC-CON-10-10-29
| Title: | Synthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1 | Authors: | Bernardo, P.H. Sivaraman, T. Wan, K.-F. Xu, J. Krishnamoorthy, J. Song, C.M. Tian, L. Chin, J.S.F. Lim, D.S.W. Mok, H.Y.K. Yu, V.C. Tong, J.C. Chai, C.L.L. |
Keywords: | B-cell lymphoma-extra large (Bcl-XL) Docking studies Drug design Myeloid cell leukemia sequence 1 (Mcl-1) Rhodanine |
Issue Date: | 2011 | Citation: | Bernardo, P.H., Sivaraman, T., Wan, K.-F., Xu, J., Krishnamoorthy, J., Song, C.M., Tian, L., Chin, J.S.F., Lim, D.S.W., Mok, H.Y.K., Yu, V.C., Tong, J.C., Chai, C.L.L. (2011). Synthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1. Pure and Applied Chemistry 83 (3) : 723-731. ScholarBank@NUS Repository. https://doi.org/10.1351/PAC-CON-10-10-29 | Abstract: | A small library of pyridine-based rhodanine analogues of BH3I-1 were synthesized and screened against B-cell lymphoma-extra large (Bcl-XL) and myeloid cell leukemia sequence 1 (Mcl-1) for the ability to displace 5-carboxyfluorescein-labeled Bak peptide (Flu-Bak). Differences in selectivity toward Bcl-XL and Mcl-1 were observed, and the binding modes of selected compounds were studied further. The results may be useful in designing potent small-molecule inhibitors of Bcl-XL and Mcl-1 as well as selective Mcl-1 inhibitors. © 2011 IUPAC. | Source Title: | Pure and Applied Chemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/101801 | ISSN: | 00334545 | DOI: | 10.1351/PAC-CON-10-10-29 |
| Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
19
checked on May 16, 2022
WEB OF SCIENCETM
Citations
19
checked on May 16, 2022
Page view(s)
182
checked on May 12, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.