Please use this identifier to cite or link to this item: https://doi.org/10.1351/PAC-CON-10-10-29
DC FieldValue
dc.titleSynthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1
dc.contributor.authorBernardo, P.H.
dc.contributor.authorSivaraman, T.
dc.contributor.authorWan, K.-F.
dc.contributor.authorXu, J.
dc.contributor.authorKrishnamoorthy, J.
dc.contributor.authorSong, C.M.
dc.contributor.authorTian, L.
dc.contributor.authorChin, J.S.F.
dc.contributor.authorLim, D.S.W.
dc.contributor.authorMok, H.Y.K.
dc.contributor.authorYu, V.C.
dc.contributor.authorTong, J.C.
dc.contributor.authorChai, C.L.L.
dc.date.accessioned2014-10-27T08:41:09Z
dc.date.available2014-10-27T08:41:09Z
dc.date.issued2011
dc.identifier.citationBernardo, P.H., Sivaraman, T., Wan, K.-F., Xu, J., Krishnamoorthy, J., Song, C.M., Tian, L., Chin, J.S.F., Lim, D.S.W., Mok, H.Y.K., Yu, V.C., Tong, J.C., Chai, C.L.L. (2011). Synthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1. Pure and Applied Chemistry 83 (3) : 723-731. ScholarBank@NUS Repository. https://doi.org/10.1351/PAC-CON-10-10-29
dc.identifier.issn00334545
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/101801
dc.description.abstractA small library of pyridine-based rhodanine analogues of BH3I-1 were synthesized and screened against B-cell lymphoma-extra large (Bcl-XL) and myeloid cell leukemia sequence 1 (Mcl-1) for the ability to displace 5-carboxyfluorescein-labeled Bak peptide (Flu-Bak). Differences in selectivity toward Bcl-XL and Mcl-1 were observed, and the binding modes of selected compounds were studied further. The results may be useful in designing potent small-molecule inhibitors of Bcl-XL and Mcl-1 as well as selective Mcl-1 inhibitors. © 2011 IUPAC.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1351/PAC-CON-10-10-29
dc.sourceScopus
dc.subjectB-cell lymphoma-extra large (Bcl-XL)
dc.subjectDocking studies
dc.subjectDrug design
dc.subjectMyeloid cell leukemia sequence 1 (Mcl-1)
dc.subjectRhodanine
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1351/PAC-CON-10-10-29
dc.description.sourcetitlePure and Applied Chemistry
dc.description.volume83
dc.description.issue3
dc.description.page723-731
dc.description.codenPACHA
dc.identifier.isiut000289643400029
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

15
checked on Nov 24, 2020

WEB OF SCIENCETM
Citations

16
checked on Nov 24, 2020

Page view(s)

101
checked on Nov 22, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.