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|Title:||Synthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1|
|Keywords:||B-cell lymphoma-extra large (Bcl-XL)|
Myeloid cell leukemia sequence 1 (Mcl-1)
|Source:||Bernardo, P.H., Sivaraman, T., Wan, K.-F., Xu, J., Krishnamoorthy, J., Song, C.M., Tian, L., Chin, J.S.F., Lim, D.S.W., Mok, H.Y.K., Yu, V.C., Tong, J.C., Chai, C.L.L. (2011). Synthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1. Pure and Applied Chemistry 83 (3) : 723-731. ScholarBank@NUS Repository. https://doi.org/10.1351/PAC-CON-10-10-29|
|Abstract:||A small library of pyridine-based rhodanine analogues of BH3I-1 were synthesized and screened against B-cell lymphoma-extra large (Bcl-XL) and myeloid cell leukemia sequence 1 (Mcl-1) for the ability to displace 5-carboxyfluorescein-labeled Bak peptide (Flu-Bak). Differences in selectivity toward Bcl-XL and Mcl-1 were observed, and the binding modes of selected compounds were studied further. The results may be useful in designing potent small-molecule inhibitors of Bcl-XL and Mcl-1 as well as selective Mcl-1 inhibitors. © 2011 IUPAC.|
|Source Title:||Pure and Applied Chemistry|
|Appears in Collections:||Staff Publications|
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