Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng1961
Title: Fgf10 regulates hepatopancreatic ductal system patterning and differentiation
Authors: Dong, P.D.S.
Munson, C.A.
Norton, W.
Crosnier, C.
Pan, X. 
Gong, Z. 
Neumann, C.J.
Stainier, D.Y.R.
Issue Date: Mar-2007
Citation: Dong, P.D.S., Munson, C.A., Norton, W., Crosnier, C., Pan, X., Gong, Z., Neumann, C.J., Stainier, D.Y.R. (2007-03). Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nature Genetics 39 (3) : 397-402. ScholarBank@NUS Repository. https://doi.org/10.1038/ng1961
Abstract: During organogenesis, the foregut endoderm gives rise to the many different cell types that comprise the hepatopancreatic system, including hepatic, pancreatic and gallbladder cells, as well as the epithelial cells of the hepatopancreatic ductal system that connects these organs together and with the intestine. However, the mechanisms responsible for demarcating ducts versus organs are poorly understood. Here, we show that Fgf10 signaling from the adjacent mesenchyme is responsible for refining the boundaries between the hepatopancreatic duct and organs. In zebrafish fgf10 mutants, the hepatopancreatic ductal epithelium is severely dysmorphic, and cells of the hepatopancreatic ductal system and adjacent intestine misdifferentiate toward hepatic and pancreatic fates. Furthermore, Fgf10 also functions to prevent the differentiation of the proximal pancreas and liver into hepatic and pancreatic cells, respectively. These data shed light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopancreatic duct, are directed toward different organ fates. © 2007 Nature Publishing Group.
Source Title: Nature Genetics
URI: http://scholarbank.nus.edu.sg/handle/10635/100678
ISSN: 10614036
DOI: 10.1038/ng1961
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

134
checked on Sep 25, 2020

WEB OF SCIENCETM
Citations

132
checked on Sep 17, 2020

Page view(s)

87
checked on Sep 26, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.