Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng1961
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dc.titleFgf10 regulates hepatopancreatic ductal system patterning and differentiation
dc.contributor.authorDong, P.D.S.
dc.contributor.authorMunson, C.A.
dc.contributor.authorNorton, W.
dc.contributor.authorCrosnier, C.
dc.contributor.authorPan, X.
dc.contributor.authorGong, Z.
dc.contributor.authorNeumann, C.J.
dc.contributor.authorStainier, D.Y.R.
dc.date.accessioned2014-10-27T08:28:29Z
dc.date.available2014-10-27T08:28:29Z
dc.date.issued2007-03
dc.identifier.citationDong, P.D.S., Munson, C.A., Norton, W., Crosnier, C., Pan, X., Gong, Z., Neumann, C.J., Stainier, D.Y.R. (2007-03). Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nature Genetics 39 (3) : 397-402. ScholarBank@NUS Repository. https://doi.org/10.1038/ng1961
dc.identifier.issn10614036
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100678
dc.description.abstractDuring organogenesis, the foregut endoderm gives rise to the many different cell types that comprise the hepatopancreatic system, including hepatic, pancreatic and gallbladder cells, as well as the epithelial cells of the hepatopancreatic ductal system that connects these organs together and with the intestine. However, the mechanisms responsible for demarcating ducts versus organs are poorly understood. Here, we show that Fgf10 signaling from the adjacent mesenchyme is responsible for refining the boundaries between the hepatopancreatic duct and organs. In zebrafish fgf10 mutants, the hepatopancreatic ductal epithelium is severely dysmorphic, and cells of the hepatopancreatic ductal system and adjacent intestine misdifferentiate toward hepatic and pancreatic fates. Furthermore, Fgf10 also functions to prevent the differentiation of the proximal pancreas and liver into hepatic and pancreatic cells, respectively. These data shed light onto how the multipotent cells of the foregut endoderm, and subsequently those of the hepatopancreatic duct, are directed toward different organ fates. © 2007 Nature Publishing Group.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/ng1961
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1038/ng1961
dc.description.sourcetitleNature Genetics
dc.description.volume39
dc.description.issue3
dc.description.page397-402
dc.description.codenNGENE
dc.identifier.isiut000244480000024
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