Please use this identifier to cite or link to this item: https://doi.org/10.1002/dvdy.20242
Title: Expression of a novel zebrafish zinc finger gene, gli2b, is affected in Hedgehog and Notch signaling related mutants during embryonic development
Authors: Ke, Z. 
Emelyanov, A.
Lim, S.E.S.
Korzh, V. 
Gong, Z. 
Keywords: Gene duplication
Hindbrain
Hypothalamus
mindbomb
Ortholog
Rhombomere
smoothened
sonic you
you too
Zinc finger
Issue Date: Feb-2005
Citation: Ke, Z., Emelyanov, A., Lim, S.E.S., Korzh, V., Gong, Z. (2005-02). Expression of a novel zebrafish zinc finger gene, gli2b, is affected in Hedgehog and Notch signaling related mutants during embryonic development. Developmental Dynamics 232 (2) : 479-486. ScholarBank@NUS Repository. https://doi.org/10.1002/dvdy.20242
Abstract: Gli zinc-finger proteins are known as downstream mediators of the evolutionary conserved Hedgehog pathway. In zebrafish, gli2 functions differently from Gli2 in mammals. This difference could be due to the gli2 duplication in teleosts evolution and partial redundancy between two duplicated genes. Here, we report a novel zebrafish gli2-like cDNA. Its structure, genetic location, and distinct expression pattern in the central nervous system suggested that this gene might represent a second gli2 of teleosts, and we named it gli2b. gli2b was expressed in the neural keel, excluding the forebrain-midbrain boundary, while gli2 expression complemented this pattern. After 24 hours postfertilization, several specific domains of gli2b expression were observed in the lateral and medial hindbrain and hypothalamus. In mutants affecting the Hedgehog and Notch signaling pathways, gli2b expression was either disrupted or extended in different regions. © 2004 Wiley-Liss, Inc.
Source Title: Developmental Dynamics
URI: http://scholarbank.nus.edu.sg/handle/10635/100637
ISSN: 10588388
DOI: 10.1002/dvdy.20242
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

15
checked on Sep 22, 2020

WEB OF SCIENCETM
Citations

15
checked on Sep 22, 2020

Page view(s)

83
checked on Sep 26, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.