Please use this identifier to cite or link to this item: https://doi.org/10.1002/dvdy.20242
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dc.titleExpression of a novel zebrafish zinc finger gene, gli2b, is affected in Hedgehog and Notch signaling related mutants during embryonic development
dc.contributor.authorKe, Z.
dc.contributor.authorEmelyanov, A.
dc.contributor.authorLim, S.E.S.
dc.contributor.authorKorzh, V.
dc.contributor.authorGong, Z.
dc.date.accessioned2014-10-27T08:28:03Z
dc.date.available2014-10-27T08:28:03Z
dc.date.issued2005-02
dc.identifier.citationKe, Z., Emelyanov, A., Lim, S.E.S., Korzh, V., Gong, Z. (2005-02). Expression of a novel zebrafish zinc finger gene, gli2b, is affected in Hedgehog and Notch signaling related mutants during embryonic development. Developmental Dynamics 232 (2) : 479-486. ScholarBank@NUS Repository. https://doi.org/10.1002/dvdy.20242
dc.identifier.issn10588388
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100637
dc.description.abstractGli zinc-finger proteins are known as downstream mediators of the evolutionary conserved Hedgehog pathway. In zebrafish, gli2 functions differently from Gli2 in mammals. This difference could be due to the gli2 duplication in teleosts evolution and partial redundancy between two duplicated genes. Here, we report a novel zebrafish gli2-like cDNA. Its structure, genetic location, and distinct expression pattern in the central nervous system suggested that this gene might represent a second gli2 of teleosts, and we named it gli2b. gli2b was expressed in the neural keel, excluding the forebrain-midbrain boundary, while gli2 expression complemented this pattern. After 24 hours postfertilization, several specific domains of gli2b expression were observed in the lateral and medial hindbrain and hypothalamus. In mutants affecting the Hedgehog and Notch signaling pathways, gli2b expression was either disrupted or extended in different regions. © 2004 Wiley-Liss, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/dvdy.20242
dc.sourceScopus
dc.subjectGene duplication
dc.subjectHindbrain
dc.subjectHypothalamus
dc.subjectmindbomb
dc.subjectOrtholog
dc.subjectRhombomere
dc.subjectsmoothened
dc.subjectsonic you
dc.subjectyou too
dc.subjectZinc finger
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1002/dvdy.20242
dc.description.sourcetitleDevelopmental Dynamics
dc.description.volume232
dc.description.issue2
dc.description.page479-486
dc.description.codenDEDYE
dc.identifier.isiut000226440900024
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