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Title: Crystal structure of mouse RhoA:GTPcS complex in a centered lattice
Authors: Jobichen, C. 
Pal, K.
Swaminathan, K. 
Keywords: Crystal structure
Small GTPases
Issue Date: Dec-2012
Citation: Jobichen, C.,Pal, K.,Swaminathan, K. (2012-12). Crystal structure of mouse RhoA:GTPcS complex in a centered lattice. Journal of Structural and Functional Genomics 13 (4) : 241-245. ScholarBank@NUS Repository.
Abstract: RhoA, a member of the Rho sub-family of small GTPases, plays a significant signaling role in cell morphogenesis, migration, neuronal development, cell division and adhesion. So far, 4 structures of RhoA:GDP/GTP analogs and 14 structures of RhoA in complex with other proteins have been reported. All RhoA:GDP/GTP analog complexes have been crystallized in primitive lattices and RhoA is monomeric. This is the first time a RhoA:GTP analog complex has been crystallized as a dimer in a centered lattice. The present structure reveals structural differences in the switch-I (residues 28-42) and switch-II (residues 61-66) regions, which play important roles in interactions with downstream targets to transduce signals, when compared to the previously reported structures. © Springer Science+Business Media B.V. 2012.
Source Title: Journal of Structural and Functional Genomics
ISSN: 1345711X
DOI: 10.1007/s10969-012-9143-5
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