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|Title:||Crystal structure of mouse RhoA:GTPcS complex in a centered lattice|
|Authors:||Jobichen, C. |
|Source:||Jobichen, C.,Pal, K.,Swaminathan, K. (2012-12). Crystal structure of mouse RhoA:GTPcS complex in a centered lattice. Journal of Structural and Functional Genomics 13 (4) : 241-245. ScholarBank@NUS Repository. https://doi.org/10.1007/s10969-012-9143-5|
|Abstract:||RhoA, a member of the Rho sub-family of small GTPases, plays a significant signaling role in cell morphogenesis, migration, neuronal development, cell division and adhesion. So far, 4 structures of RhoA:GDP/GTP analogs and 14 structures of RhoA in complex with other proteins have been reported. All RhoA:GDP/GTP analog complexes have been crystallized in primitive lattices and RhoA is monomeric. This is the first time a RhoA:GTP analog complex has been crystallized as a dimer in a centered lattice. The present structure reveals structural differences in the switch-I (residues 28-42) and switch-II (residues 61-66) regions, which play important roles in interactions with downstream targets to transduce signals, when compared to the previously reported structures. © Springer Science+Business Media B.V. 2012.|
|Source Title:||Journal of Structural and Functional Genomics|
|Appears in Collections:||Staff Publications|
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