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|Title:||Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum||Authors:||Itoigawa, M.
Cancer chemopreventive agents
Epstein-Barr virus activation
Two-stage mouse skin carcinogenesis
|Issue Date:||10-Aug-2001||Citation:||Itoigawa, M., Ito, C., Tan, H.T.-W., Kuchide, M., Tokuda, H., Nishino, H., Furukawa, H. (2001-08-10). Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum. Cancer Letters 169 (1) : 15-19. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3835(01)00521-3||Abstract:||In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All of the compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Calocoumarin-A (5) showed more potent activity than any of the other compounds tested. Furthermore, calocoumarin-A (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that some of these 4-phenylcoumarins might be valuable as potential cancer chemopreventive agents (anti-tumor-promoters). © 2001 Elsevier Science Ireland Ltd.||Source Title:||Cancer Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/100211||ISSN:||03043835||DOI:||10.1016/S0304-3835(01)00521-3|
|Appears in Collections:||Staff Publications|
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