Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3835(01)00521-3
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dc.titleCancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum
dc.contributor.authorItoigawa, M.
dc.contributor.authorIto, C.
dc.contributor.authorTan, H.T.-W.
dc.contributor.authorKuchide, M.
dc.contributor.authorTokuda, H.
dc.contributor.authorNishino, H.
dc.contributor.authorFurukawa, H.
dc.date.accessioned2014-10-27T08:23:17Z
dc.date.available2014-10-27T08:23:17Z
dc.date.issued2001-08-10
dc.identifier.citationItoigawa, M., Ito, C., Tan, H.T.-W., Kuchide, M., Tokuda, H., Nishino, H., Furukawa, H. (2001-08-10). Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum. Cancer Letters 169 (1) : 15-19. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3835(01)00521-3
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100211
dc.description.abstractIn a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All of the compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Calocoumarin-A (5) showed more potent activity than any of the other compounds tested. Furthermore, calocoumarin-A (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that some of these 4-phenylcoumarins might be valuable as potential cancer chemopreventive agents (anti-tumor-promoters). © 2001 Elsevier Science Ireland Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0304-3835(01)00521-3
dc.sourceScopus
dc.subject4-Phenylcoumarins
dc.subjectAnti-tumor-promoting effect
dc.subjectCalophyllum inophyllum
dc.subjectCancer chemopreventive agents
dc.subjectEpstein-Barr virus activation
dc.subjectTwo-stage mouse skin carcinogenesis
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/S0304-3835(01)00521-3
dc.description.sourcetitleCancer Letters
dc.description.volume169
dc.description.issue1
dc.description.page15-19
dc.description.codenCALED
dc.identifier.isiut000169702100003
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