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https://doi.org/10.1016/S0304-3835(01)00521-3
DC Field | Value | |
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dc.title | Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum | |
dc.contributor.author | Itoigawa, M. | |
dc.contributor.author | Ito, C. | |
dc.contributor.author | Tan, H.T.-W. | |
dc.contributor.author | Kuchide, M. | |
dc.contributor.author | Tokuda, H. | |
dc.contributor.author | Nishino, H. | |
dc.contributor.author | Furukawa, H. | |
dc.date.accessioned | 2014-10-27T08:23:17Z | |
dc.date.available | 2014-10-27T08:23:17Z | |
dc.date.issued | 2001-08-10 | |
dc.identifier.citation | Itoigawa, M., Ito, C., Tan, H.T.-W., Kuchide, M., Tokuda, H., Nishino, H., Furukawa, H. (2001-08-10). Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum. Cancer Letters 169 (1) : 15-19. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3835(01)00521-3 | |
dc.identifier.issn | 03043835 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/100211 | |
dc.description.abstract | In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All of the compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Calocoumarin-A (5) showed more potent activity than any of the other compounds tested. Furthermore, calocoumarin-A (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that some of these 4-phenylcoumarins might be valuable as potential cancer chemopreventive agents (anti-tumor-promoters). © 2001 Elsevier Science Ireland Ltd. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0304-3835(01)00521-3 | |
dc.source | Scopus | |
dc.subject | 4-Phenylcoumarins | |
dc.subject | Anti-tumor-promoting effect | |
dc.subject | Calophyllum inophyllum | |
dc.subject | Cancer chemopreventive agents | |
dc.subject | Epstein-Barr virus activation | |
dc.subject | Two-stage mouse skin carcinogenesis | |
dc.type | Article | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.description.doi | 10.1016/S0304-3835(01)00521-3 | |
dc.description.sourcetitle | Cancer Letters | |
dc.description.volume | 169 | |
dc.description.issue | 1 | |
dc.description.page | 15-19 | |
dc.description.coden | CALED | |
dc.identifier.isiut | 000169702100003 | |
Appears in Collections: | Staff Publications |
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