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Title: Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum
Authors: Itoigawa, M.
Ito, C.
Tan, H.T.-W. 
Kuchide, M.
Tokuda, H.
Nishino, H.
Furukawa, H.
Keywords: 4-Phenylcoumarins
Anti-tumor-promoting effect
Calophyllum inophyllum
Cancer chemopreventive agents
Epstein-Barr virus activation
Two-stage mouse skin carcinogenesis
Issue Date: 10-Aug-2001
Citation: Itoigawa, M., Ito, C., Tan, H.T.-W., Kuchide, M., Tokuda, H., Nishino, H., Furukawa, H. (2001-08-10). Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum. Cancer Letters 169 (1) : 15-19. ScholarBank@NUS Repository.
Abstract: In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All of the compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Calocoumarin-A (5) showed more potent activity than any of the other compounds tested. Furthermore, calocoumarin-A (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that some of these 4-phenylcoumarins might be valuable as potential cancer chemopreventive agents (anti-tumor-promoters). © 2001 Elsevier Science Ireland Ltd.
Source Title: Cancer Letters
ISSN: 03043835
DOI: 10.1016/S0304-3835(01)00521-3
Appears in Collections:Staff Publications

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