Please use this identifier to cite or link to this item:
Title: Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum
Authors: Itoigawa, M.
Ito, C.
Tan, H.T.-W. 
Kuchide, M.
Tokuda, H.
Nishino, H.
Furukawa, H.
Keywords: 4-Phenylcoumarins
Anti-tumor-promoting effect
Calophyllum inophyllum
Cancer chemopreventive agents
Epstein-Barr virus activation
Two-stage mouse skin carcinogenesis
Issue Date: 10-Aug-2001
Citation: Itoigawa, M., Ito, C., Tan, H.T.-W., Kuchide, M., Tokuda, H., Nishino, H., Furukawa, H. (2001-08-10). Cancer chemopreventive agents, 4-phenylcoumarins from Calophyllum inophyllum. Cancer Letters 169 (1) : 15-19. ScholarBank@NUS Repository.
Abstract: In a search for anti-tumor-promoting agents, we carried out a primary screening of ten 4-phenylcoumarins isolated from Calophyllum inophyllum L. (Guttiferae), by examining their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. All of the compounds tested in this study showed inhibitory activity against EBV, without showing any cytotoxicity. Calocoumarin-A (5) showed more potent activity than any of the other compounds tested. Furthermore, calocoumarin-A (5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The results of the present investigation indicate that some of these 4-phenylcoumarins might be valuable as potential cancer chemopreventive agents (anti-tumor-promoters). © 2001 Elsevier Science Ireland Ltd.
Source Title: Cancer Letters
ISSN: 03043835
DOI: 10.1016/S0304-3835(01)00521-3
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Sep 15, 2023


checked on Sep 15, 2023

Page view(s)

checked on Sep 21, 2023

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.