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Title: Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants
Authors: Itoigawa, M.
Ito, C.
Tan, H.T.-W. 
Okuda, M.
Tokuda, H.
Nishino, H.
Furukawa, H.
Keywords: Anti-tumor-promoting effect
Avicennia plants
Cancer chemopreventive agents
Epstein-Barr virus activation
Two-stage mouse skin carcinogenesis
Issue Date: 28-Dec-2001
Citation: Itoigawa, M., Ito, C., Tan, H.T.-W., Okuda, M., Tokuda, H., Nishino, H., Furukawa, H. (2001-12-28). Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants. Cancer Letters 174 (2) : 135-139. ScholarBank@NUS Repository.
Abstract: As a part of screening studies for cancer chemopreventive agents (anti-tumor promoters), six natural and four synthetic naphthoquinones and five of their analogs were tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Some of the 1,4-naphthoquinones and their analogs were found to show remarkably potent activities, without showing any cytotoxicity. 1,4-Furanonaphthoquinone (5) and its analog (9) isolated from Avicennia plants (Avicenniaceae), having an alcoholic OH group on the dihydrofuran-ring, displayed the most potent activity. Furthermore, avicenol-A (9) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The result of the present investigation indicated that some of these 1,4-naphthoquinones and their analogs might be valuable as potent cancer chemopreventive agents. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
Source Title: Cancer Letters
ISSN: 03043835
DOI: 10.1016/S0304-3835(01)00707-8
Appears in Collections:Staff Publications

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