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|Title:||Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants||Authors:||Itoigawa, M.
Cancer chemopreventive agents
Epstein-Barr virus activation
Two-stage mouse skin carcinogenesis
|Issue Date:||28-Dec-2001||Citation:||Itoigawa, M., Ito, C., Tan, H.T.-W., Okuda, M., Tokuda, H., Nishino, H., Furukawa, H. (2001-12-28). Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants. Cancer Letters 174 (2) : 135-139. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3835(01)00707-8||Abstract:||As a part of screening studies for cancer chemopreventive agents (anti-tumor promoters), six natural and four synthetic naphthoquinones and five of their analogs were tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Some of the 1,4-naphthoquinones and their analogs were found to show remarkably potent activities, without showing any cytotoxicity. 1,4-Furanonaphthoquinone (5) and its analog (9) isolated from Avicennia plants (Avicenniaceae), having an alcoholic OH group on the dihydrofuran-ring, displayed the most potent activity. Furthermore, avicenol-A (9) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The result of the present investigation indicated that some of these 1,4-naphthoquinones and their analogs might be valuable as potent cancer chemopreventive agents. © 2001 Elsevier Science Ireland Ltd. All rights reserved.||Source Title:||Cancer Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/100209||ISSN:||03043835||DOI:||10.1016/S0304-3835(01)00707-8|
|Appears in Collections:||Staff Publications|
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