Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0304-3835(01)00707-8
DC FieldValue
dc.titleCancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants
dc.contributor.authorItoigawa, M.
dc.contributor.authorIto, C.
dc.contributor.authorTan, H.T.-W.
dc.contributor.authorOkuda, M.
dc.contributor.authorTokuda, H.
dc.contributor.authorNishino, H.
dc.contributor.authorFurukawa, H.
dc.date.accessioned2014-10-27T08:23:15Z
dc.date.available2014-10-27T08:23:15Z
dc.date.issued2001-12-28
dc.identifier.citationItoigawa, M., Ito, C., Tan, H.T.-W., Okuda, M., Tokuda, H., Nishino, H., Furukawa, H. (2001-12-28). Cancer chemopreventive activity of naphthoquinones and their analogs from Avicennia plants. Cancer Letters 174 (2) : 135-139. ScholarBank@NUS Repository. https://doi.org/10.1016/S0304-3835(01)00707-8
dc.identifier.issn03043835
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/100209
dc.description.abstractAs a part of screening studies for cancer chemopreventive agents (anti-tumor promoters), six natural and four synthetic naphthoquinones and five of their analogs were tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Some of the 1,4-naphthoquinones and their analogs were found to show remarkably potent activities, without showing any cytotoxicity. 1,4-Furanonaphthoquinone (5) and its analog (9) isolated from Avicennia plants (Avicenniaceae), having an alcoholic OH group on the dihydrofuran-ring, displayed the most potent activity. Furthermore, avicenol-A (9) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. The result of the present investigation indicated that some of these 1,4-naphthoquinones and their analogs might be valuable as potent cancer chemopreventive agents. © 2001 Elsevier Science Ireland Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0304-3835(01)00707-8
dc.sourceScopus
dc.subjectAnti-tumor-promoting effect
dc.subjectAvicennia plants
dc.subjectCancer chemopreventive agents
dc.subjectEpstein-Barr virus activation
dc.subjectNaphthoquinones
dc.subjectTwo-stage mouse skin carcinogenesis
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/S0304-3835(01)00707-8
dc.description.sourcetitleCancer Letters
dc.description.volume174
dc.description.issue2
dc.description.page135-139
dc.description.codenCALED
dc.identifier.isiut000172255500004
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

66
checked on Jan 17, 2020

WEB OF SCIENCETM
Citations

50
checked on Jan 17, 2020

Page view(s)

98
checked on Jan 11, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.