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|Title:||A novel antitumour compound from the mucus of a coral, galaxea fascicularis, inhibits topoisomerase I and II||Authors:||Fung, F.M.Y.
|Issue Date:||Jul-1998||Citation:||Fung, F.M.Y., Ding, J.L. (1998-07). A novel antitumour compound from the mucus of a coral, galaxea fascicularis, inhibits topoisomerase I and II. Toxicon 36 (7) : 1053-1058. ScholarBank@NUS Repository. https://doi.org/10.1016/S0041-0101(97)00098-6||Abstract:||S2 isolated from the mucus of G. fascicularis contains anti- topoisomerase activity, causing cytotoxicity to a multiple-drug resistant leukaemia cell line, P388/VCR. It inhibits DNA relaxation catalysed by topoisomerase I and II. S2 stabilised the topoisomerase I-DNA cleavable complex, thereby inhibiting the DNA replication machinery, leading to cell death. The active centre of S2 probably contains a Galβ(1-4)GlcNAc dissacharide linkage. S2 has potentials of being developed into a new anticancer therapeutic.||Source Title:||Toxicon||URI:||http://scholarbank.nus.edu.sg/handle/10635/99917||ISSN:||00410101||DOI:||10.1016/S0041-0101(97)00098-6|
|Appears in Collections:||Staff Publications|
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