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Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0041-0101(97)00098-6
DC FieldValue
dc.titleA novel antitumour compound from the mucus of a coral, galaxea fascicularis, inhibits topoisomerase I and II
dc.contributor.authorFung, F.M.Y.
dc.contributor.authorDing, J.L.
dc.date.accessioned2014-10-27T08:20:00Z
dc.date.available2014-10-27T08:20:00Z
dc.date.issued1998-07
dc.identifier.citationFung, F.M.Y., Ding, J.L. (1998-07). A novel antitumour compound from the mucus of a coral, galaxea fascicularis, inhibits topoisomerase I and II. Toxicon 36 (7) : 1053-1058. ScholarBank@NUS Repository. https://doi.org/10.1016/S0041-0101(97)00098-6
dc.identifier.issn00410101
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/99917
dc.description.abstractS2 isolated from the mucus of G. fascicularis contains anti- topoisomerase activity, causing cytotoxicity to a multiple-drug resistant leukaemia cell line, P388/VCR. It inhibits DNA relaxation catalysed by topoisomerase I and II. S2 stabilised the topoisomerase I-DNA cleavable complex, thereby inhibiting the DNA replication machinery, leading to cell death. The active centre of S2 probably contains a Galβ(1-4)GlcNAc dissacharide linkage. S2 has potentials of being developed into a new anticancer therapeutic.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0041-0101(97)00098-6
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1016/S0041-0101(97)00098-6
dc.description.sourcetitleToxicon
dc.description.volume36
dc.description.issue7
dc.description.page1053-1058
dc.description.codenTOXIA
dc.identifier.isiut000074652700010
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