Please use this identifier to cite or link to this item:
Title: A matrix protein silences transposons and repeats through interaction with retinoblastoma-associated proteins
Authors: Xu, Y.
Wang, Y.
Stroud, H.
Gu, X. 
Sun, B.
Gan, E.-S.
Ng, K.-H.
Jacobsen, S.E.
He, Y. 
Ito, T. 
Issue Date: 18-Feb-2013
Citation: Xu, Y., Wang, Y., Stroud, H., Gu, X., Sun, B., Gan, E.-S., Ng, K.-H., Jacobsen, S.E., He, Y., Ito, T. (2013-02-18). A matrix protein silences transposons and repeats through interaction with retinoblastoma-associated proteins. Current Biology 23 (4) : 345-350. ScholarBank@NUS Repository.
Abstract: Epigenetic regulation helps to maintain genomic integrity by suppressing transposable elements (TEs) and also controls key developmental processes, such as flowering time [1-3]. To prevent TEs from causing rearrangements and mutations, TE and TE-like repetitive DNA sequences are usually methylated, whereas histones are hypoacetylated and methylated on specific residues (e.g., H3 lysine 9 dimethylation [H3K9me2]) [4, 5]. TEs and repeats can also attenuate gene expression [2, 6-8]. However, how various histone modifiers are recruited to target loci is not well understood. Here we show that knockdown of the nuclear matrix protein with AT-hook DNA binding motifs [9-11] TRANSPOSABLE ELEMENT SILENCING VIA AT-HOOK (TEK) in Arabidopsis Landsberg erecta results in robust activation of various TEs, the TE-like repeat-containing floral repressor genes FLOWERING LOCUS C (FLC) and FWA [1, 2, 12]. This derepression is associated with chromatin conformational changes, increased histone acetylation, reduced H3K9me2, and even TE transposition. TEK directly binds to an FLC-repressive regulatory region and the silencing repeats of FWA and associates with Arabidopsis homologs of the Retinoblastoma-associated protein 46/48, FVE and MSI5, which mediate histone deacetylation [13, 14]. We propose that the nuclear matrix protein TEK acts in the maintenance of genome integrity by silencing TE and repeat-containing genes. © 2013 Elsevier Ltd.
Source Title: Current Biology
ISSN: 09609822
DOI: 10.1016/j.cub.2013.01.030
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 19, 2022


checked on Jan 19, 2022

Page view(s)

checked on Jan 20, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.