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|Title:||A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo||Authors:||Ng, T.
|Issue Date:||May-2006||Citation:||Ng, T., Yu, F., Roy, S. (2006-05). A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo. Development Genes and Evolution 216 (5) : 243-252. ScholarBank@NUS Repository. https://doi.org/10.1007/s00427-005-0044-5||Abstract:||The B-lymphocyte-inducing maturation protein (Blimp-1) gene encodes a zinc finger and SET/PR domain-containing transcriptional factor. A number of functional studies in a variety of vertebrate species have demonstrated that Blimp-1 is a master regulator of cell fate determination and cell differentiation in a wide diversity of developmental contexts. Despite all of this significance, the role, if any, of a homologue of Blimp-1 in directing morphogenetic events during embryonic development of invertebrates has so far remained completely unexplored. In this report, we describe the identification of a Drosophila homologue of Blimp-1 and show that the gene is expressed in diverse cell types during the course of embryogenesis. Further, using genetic analysis, we demonstrate that its wild-type activity is critically required for the maturation of the tracheal system into properly differentiated tubes. © Springer-Verlag 2006.||Source Title:||Development Genes and Evolution||URI:||http://scholarbank.nus.edu.sg/handle/10635/99844||ISSN:||0949944X||DOI:||10.1007/s00427-005-0044-5|
|Appears in Collections:||Staff Publications|
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