Please use this identifier to cite or link to this item:
|Title:||A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo|
|Source:||Ng, T., Yu, F., Roy, S. (2006-05). A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo. Development Genes and Evolution 216 (5) : 243-252. ScholarBank@NUS Repository. https://doi.org/10.1007/s00427-005-0044-5|
|Abstract:||The B-lymphocyte-inducing maturation protein (Blimp-1) gene encodes a zinc finger and SET/PR domain-containing transcriptional factor. A number of functional studies in a variety of vertebrate species have demonstrated that Blimp-1 is a master regulator of cell fate determination and cell differentiation in a wide diversity of developmental contexts. Despite all of this significance, the role, if any, of a homologue of Blimp-1 in directing morphogenetic events during embryonic development of invertebrates has so far remained completely unexplored. In this report, we describe the identification of a Drosophila homologue of Blimp-1 and show that the gene is expressed in diverse cell types during the course of embryogenesis. Further, using genetic analysis, we demonstrate that its wild-type activity is critically required for the maturation of the tracheal system into properly differentiated tubes. © Springer-Verlag 2006.|
|Source Title:||Development Genes and Evolution|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 28, 2018
WEB OF SCIENCETM
checked on Feb 20, 2018
checked on Mar 12, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.