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Title: The stretched intermediate model of B-Z DNA transition
Authors: Lim, W.
Feng, Y.P. 
Issue Date: Mar-2005
Citation: Lim, W., Feng, Y.P. (2005-03). The stretched intermediate model of B-Z DNA transition. Biophysical Journal 88 (3) : 1593-1607. ScholarBank@NUS Repository.
Abstract: There have been numerous attempts to describe the mechanism of B-Z transition. Our simulations based on the stochastic difference equation with length algorithm show that a short DNA oligomer will tend to unwind and overstretch during the transition. The overstretching of DNA is then understood from the Zhou, Zhang, and Ou-Yang model. Unlike the Harvey model, the stretched intermediate model does not pose any steric dilemma; we are able to show that the chain sense reversal progresses spontaneously using the stretched intermediate model. A nonlinear DNA model is used to describe the origins and mechanism of base rotation in the stretched intermediate state of DNA. We also propose an experiment that can verify the existence of a stretched intermediate state during B-Z transition, thus opening up fresh grounds for experimentation in this field. © 2005 by the Biophysical Society.
Source Title: Biophysical Journal
ISSN: 00063495
DOI: 10.1529/biophysj.104.052027
Appears in Collections:Staff Publications

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