Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/95567
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dc.titleMicroRNAs: Biogenesis, function and applications
dc.contributor.authorChua, J.H.
dc.contributor.authorArmugam, A.
dc.contributor.authorJeyaseelan, K.
dc.date.accessioned2014-10-16T08:49:23Z
dc.date.available2014-10-16T08:49:23Z
dc.date.issued2009
dc.identifier.citationChua, J.H.,Armugam, A.,Jeyaseelan, K. (2009). MicroRNAs: Biogenesis, function and applications. Current Opinion in Molecular Therapeutics 11 (2) : 189-199. ScholarBank@NUS Repository.
dc.identifier.issn14648431
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/95567
dc.description.abstractMicroRNAs (miRNAs) belong to the group of non-coding, small RNAs (19 to 21 nucleotide-long oligonucleotides) that are endogenously produced from their own genes. miRNAs interfere with or affect the transcription or translation of other genes, resulting in gene silencing or activation by a process known as RNAi or RNA activation, respectively. The discovery of miRNAs and related small RNAs within the last 10 years has opened up a new field in biology, called RNomics, which investigates differences in RNA populations and offers great potential in correcting the regulation of abnormally expressed and disease-causing genes, as well as in the development of novel therapeutic agents. This review focuses on the developments in miRNAs and their potential therapeutic applications. © Thomson Reuters (Scientific) Ltd.
dc.sourceScopus
dc.subjectAntagomir
dc.subjectBiomarker
dc.subjectGene silencing
dc.subjectMiRNA
dc.subjectSiRNA
dc.subjectTherapeutic
dc.typeReview
dc.contributor.departmentCHEMISTRY
dc.description.sourcetitleCurrent Opinion in Molecular Therapeutics
dc.description.volume11
dc.description.issue2
dc.description.page189-199
dc.description.codenCUOTF
dc.identifier.isiutNOT_IN_WOS
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