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Title: MicroRNAs: Biogenesis, function and applications
Authors: Chua, J.H. 
Armugam, A.
Jeyaseelan, K.
Keywords: Antagomir
Gene silencing
Issue Date: 2009
Citation: Chua, J.H.,Armugam, A.,Jeyaseelan, K. (2009). MicroRNAs: Biogenesis, function and applications. Current Opinion in Molecular Therapeutics 11 (2) : 189-199. ScholarBank@NUS Repository.
Abstract: MicroRNAs (miRNAs) belong to the group of non-coding, small RNAs (19 to 21 nucleotide-long oligonucleotides) that are endogenously produced from their own genes. miRNAs interfere with or affect the transcription or translation of other genes, resulting in gene silencing or activation by a process known as RNAi or RNA activation, respectively. The discovery of miRNAs and related small RNAs within the last 10 years has opened up a new field in biology, called RNomics, which investigates differences in RNA populations and offers great potential in correcting the regulation of abnormally expressed and disease-causing genes, as well as in the development of novel therapeutic agents. This review focuses on the developments in miRNAs and their potential therapeutic applications. © Thomson Reuters (Scientific) Ltd.
Source Title: Current Opinion in Molecular Therapeutics
ISSN: 14648431
Appears in Collections:Staff Publications

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