Catalytic reactions of chiral guanidines and guanidinium salts

Abstract

This account chronicles our discovery and development of catalytic reactions using chiral guanidines and guanidinium salts. 1 Introduction 2 Chiral Guanidines as Brnsted Bases 2.1 Synthetic Route for the Catalyst 2.2 Michael Reactions 2.3 Henry Reactions 2.4 Phospha-Michael Reactions 2.5 Diels-Alder Reactions 2.6 Protonation Reactions 2.7 Isomerization Reactions 2.8 Mannich Reactions 3 Catalytic Reactions of Chiral Guanidinium Salts 3.1 Michael Reactions 3.2 Phospha-Mannich Reactions 4 Chiral Guanidines as Ligands 5 Conclusions and Outlook.