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Title: Tailored albumin-based copolymers for receptor-mediated delivery of perylenediimide guest molecules
Authors: Eisele, K.
Gropeanu, R.
Musante, A.
Glasser, G.
Li, C.
Muellen, K.
Weil, T. 
Keywords: Copolymer
Folic acid
Human serum albumin
Protein hybrid
Issue Date: 1-Sep-2010
Citation: Eisele, K., Gropeanu, R., Musante, A., Glasser, G., Li, C., Muellen, K., Weil, T. (2010-09-01). Tailored albumin-based copolymers for receptor-mediated delivery of perylenediimide guest molecules. Macromolecular Rapid Communications 31 (17) : 1501-1508. ScholarBank@NUS Repository.
Abstract: Figure Presented The synthesis of a novel and multifunctional copolymer based on a human serum albumin backbone bearing several folic acid as well as PEO groups was presented. In solution, this sidechain copolymer adopts a globular architecture and about five molecules of the waterinsoluble chromophore PDI were successfully incorporated into these micelles for receptor-mediated cell uptake investigations. A significant uptake of these bioconjugates via receptor-mediated endocytosis was detected for cells expressing folic acid receptors in the cell membrane. These novel albumin-based copolymers could serve as efficient and biocompatible carrier systems facilitating the directed delivery of lipophilic drug molecules into cancer cells and they allow investigating vesicle formation and trafficking even at the single molecule level. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Macromolecular Rapid Communications
ISSN: 10221336
DOI: 10.1002/marc.201000176
Appears in Collections:Staff Publications

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